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TitleThe Structural Basis for the Specificity of Retinoid-X Receptor-Selective Agonists: New Insights Into the Role of Helix H12
Journal, issue, pagesJ. Biol. Chem., Vol. 277, Page 11385-, Year 2002
Publish dateMar 21, 2001 (structure data deposition date)
AuthorsLove, J.D. / Gooch, J.T. / Benko, S. / Li, C. / Nagy, L. / Chatterjee, V.K.K. / Evans, R.M. / Schwabe, J.W.R.
External linksJ. Biol. Chem. / PubMed:11782480
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-1h9u:
The structure of the human retinoid-X-receptor beta ligand binding domain in complex with the specific synthetic agonist LG100268
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-LG2:
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID

ChemComp-NI:
NICKEL (II) ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsNUCLEAR RECEPTOR / RXR / TRANSCRIPTION FACTOR

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