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TitleDiscovery of Further Pyrrolidine Trans-Lactams as Inhibitors of Human Neutrophil Elastase (Hne) with Potential as Development Candidates and the Crystal Structure of Hne Complexed with an Inhibitor (Gw475151)
Journal, issue, pagesJ. Med. Chem., Vol. 45, Page 3878-, Year 2002
Publish dateJul 5, 2002 (structure data deposition date)
AuthorsMacdonald, S.J.F. / Dowle, M.D. / Harrison, L.A. / Clarke, G.D.E. / Inglis, G.G.A. / Johnson, M.R. / Shah, P. / Smith, R.A. / Amour, A. / Fleetwood, G. ...Macdonald, S.J.F. / Dowle, M.D. / Harrison, L.A. / Clarke, G.D.E. / Inglis, G.G.A. / Johnson, M.R. / Shah, P. / Smith, R.A. / Amour, A. / Fleetwood, G. / Humphreys, D.C. / Molloy, C.R. / Dixon, M. / Godward, R.E. / Wonacott, A.J. / Singh, O.M.P. / Hodgson, S.T. / Hardy, G.W.
External linksJ. Med. Chem. / PubMed:12190311
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1h1b:
Crystal structure of human neutrophil elastase complexed with an inhibitor (GW475151)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-151:
(2S)-3-METHYL-2-((2R,3S)-3-[(METHYLSULFONYL)AMINO]-1-{[2-(PYRROLIDIN-1-YLMETHYL)-1,3-OXAZOL-4-YL]CARBONYL}PYRROLIDIN-2-YL)BUTANOIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / SERINE PROTEASE

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