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Structure paper

TitleCrystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases.
Journal, issue, pagesBiochemistry, Vol. 35, Page 10627-10633, Year 1996
Publish dateMay 4, 1996 (structure data deposition date)
AuthorsHong, L. / Treharne, A. / Hartsuck, J.A. / Foundling, S. / Tang, J.
External linksBiochemistry / PubMed:8718851
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-1gnm:
HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR)
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1gnn:
HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASN (V82N) COMPLEXED WITH U89360E (INHIBITOR)
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1gno:
HIV-1 PROTEASE (WILD TYPE) COMPLEXED WITH U89360E (INHIBITOR)
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-U0E:
N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsHYDROLASE (ACID PROTEASE) / ASPARTIC PROTEASE / HIV / MUTANT / INHIBITOR / U-89360E

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