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TitleSolution structure of Co(III)-bleomycin-OOH bound to a phosphoglycolate lesion containing oligonucleotide: implications for bleomycin-induced double-strand DNA cleavage.
Journal, issue, pagesBiochemistry, Vol. 40, Page 5894-5905, Year 2001
Publish dateNov 1, 2000 (structure data deposition date)
AuthorsHoehn, S.T. / Junker, H.D. / Bunt, R.C. / Turner, C.J. / Stubbe, J.
External linksBiochemistry / PubMed:11352724
MethodsNMR (solution)
Structure data

PDB-1g5l:
CO(III)-BLEOMYCIN-OOH BOUND TO AN OLIGONUCLEOTIDE CONTAINING A PHOSPHOGLYCOLATE LESION
Method: SOLUTION NMR

PDB-1gj2:
CO(III)-BLEOMYCIN-OOH BOUND TO AN OLIGONUCLEOTIDE CONTAINING A PHOSPHOGLYCOLATE LESION
Method: SOLUTION NMR

Chemicals

ChemComp-PGA:
2-PHOSPHOGLYCOLIC ACID

ChemComp-3CO:
COBALT (III) ION

ChemComp-O:
OXYGEN ATOM

ChemComp-BLB:
BLEOMYCIN B2

ChemComp-PEO:
HYDROGEN PEROXIDE

KeywordsDNA / damaged DNA / DNA-drug complex / intercalation

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