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Structure paper

TitleMechanism-based design of a protein kinase inhibitor.
Journal, issue, pagesNat. Struct. Biol., Vol. 8, Page 37-41, Year 2001
Publish dateNov 29, 2000 (structure data deposition date)
AuthorsParang, K. / Till, J.H. / Ablooglu, A.J. / Kohanski, R.A. / Hubbard, S.R. / Cole, P.A.
External linksNat. Struct. Biol. / PubMed:11135668
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-1gag:
CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-112:
THIOPHOSPHORIC ACID O-((ADENOSYL-PHOSPHO)PHOSPHO)-S-ACETAMIDYL-DIESTER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / PROTEIN KINASE INHIBITOR / TYROSINE KINASE / transferase / signaling protein / transferase-transferase inhibitor complex

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