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TitleStructural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
Journal, issue, pagesSTRUCTURE FOLD. DES., Vol. 8, Page 1089-1094, Year 2000
Publish dateAug 9, 2000 (structure data deposition date)
AuthorsRen, J. / Milton, J. / Weaver, K.L. / Short, S.A. / Stuart, D.I. / Stammers, D.K.
External linksSTRUCTURE FOLD. DES. / PubMed:11080630
MethodsX-ray diffraction
Resolution2.5 - 2.9 Å
Structure data

PDB-1fk9:
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1fko:
CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-1fkp:
CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-EFZ:
(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE / medication, antiretroviral*YM

ChemComp-HOH:
WATER

ChemComp-NVP:
11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE / medication, antiretroviral*YM

Source
  • human immunodeficiency virus 1
KeywordsTRANSFERASE / HIV-1 reverse transcriptase / AIDS / non-nucleoside inhibitor / DMP-266 / Efavirenz / drug design / drug resistance mutation / nevirapine

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