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TitleMolecular basis of agonism and antagonism in the oestrogen receptor.
Journal, issue, pagesNature, Vol. 389, Page 753-758, Year 1997
Publish dateSep 8, 1997 (structure data deposition date)
AuthorsBrzozowski, A.M. / Pike, A.C. / Dauter, Z. / Hubbard, R.E. / Bonn, T. / Engstrom, O. / Ohman, L. / Greene, G.L. / Gustafsson, J.A. / Carlquist, M.
External linksNature / PubMed:9338790
MethodsX-ray diffraction
Resolution2.6 - 3.1 Å
Structure data

PDB-1ere:
HUMAN ESTROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH 17BETA-ESTRADIOL
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-1err:
HUMAN ESTROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-EST:
ESTRADIOL

ChemComp-HOH:
WATER

ChemComp-RAL:
RALOXIFENE

Source
  • homo sapiens (human)
KeywordsNUCLEAR RECEPTOR / TRANSCRIPTION FACTOR / STEROID / AGONIST / ANTAGONIST

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