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Structure paper

Title2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
Journal, issue, pagesJ. Biol. Chem., Vol. 275, Page 7101-7108, Year 2000
Publish dateApr 14, 2000 (structure data deposition date)
AuthorsAndersen, H.S. / Iversen, L.F. / Jeppesen, C.B. / Branner, S. / Norris, K. / Rasmussen, H.B. / Moller, K.B. / Moller, N.P.
External linksJ. Biol. Chem. / PubMed:10702277
MethodsX-ray diffraction
Resolution1.8 - 2.72 Å
Structure data

PDB-1c83:
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-1c84:
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-1c85:
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID
Method: X-RAY DIFFRACTION / Resolution: 2.72 Å

PDB-1ecv:
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-OAI:
6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID

ChemComp-HOH:
WATER

ChemComp-761:
3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXYLIC ACID

ChemComp-OBA:
2-(OXALYL-AMINO)-BENZOIC ACID

ChemComp-ACT:
ACETATE ION

ChemComp-878:
5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PHOSPHORYLATION / LIGAND / INHIBITOR

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