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TitleInhibitor Binding to Active and Inactive Cdk2: The Crystal Structure of Cdk2-Cyclin A/Indirubin-5-Sulphonate
Journal, issue, pagesStructure, Vol. 9, Page 389-, Year 2001
Publish dateOct 16, 2000 (structure data deposition date)
AuthorsDavies, T.G. / Tunnah, P. / Meijer, L. / Marko, D. / Eisenbrand, G. / Endicott, J.A. / Noble, M.E.
External linksStructure / PubMed:11377199
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1e9h:
Thr 160 phosphorylated CDK2 - Human cyclin A3 complex with the inhibitor indirubin-5-sulphonate bound
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-INR:
2',3-DIOXO-1,1',2',3-TETRAHYDRO-2,3'-BIINDOLE-5'-SULFONIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / COMPLEX (PROTEIN KINASE-CYCLIN) / KINASES / INHIBITOR / CYCLIN / COMPLEX / PHOSPHORYLATION

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