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-Structure paper
Title | Kinetics and Crystal Structure of the Wild-Type and the Engineered Y101F Mutant of Herpes Simplex Virus Type 1 Thymidine Kinase Interacting with (North)-Methanocarba-Thymidine |
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Journal, issue, pages | Biochemistry, Vol. 39, Page 9597-, Year 2000 |
Publish date | May 23, 2000 (structure data deposition date) |
Authors | Prota, A. / Vogt, J. / Pilger, B. / Perozzo, R. / Wurth, C. / Marquez, V. / Russ, P. / Schulz, G.E. / Folkers, G. / Scapozza, L. |
External links | Biochemistry / PubMed:10924157 |
Methods | X-ray diffraction |
Resolution | 1.7 - 2.4 Å |
Structure data | PDB-1e2k: PDB-1e2l: |
Chemicals | ChemComp-SO4: ChemComp-TMC: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / THYMIDINE KINASE / ANTIVIRAL DRUG / ENZYME-PRODRUG GENE THERAPY / SUGAR RING PUCKER |