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TitleNucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography
Journal, issue, pagesProteins: Struct. ,Funct. , Genet., Vol. 41, Page 545-, Year 2000
Publish dateMay 23, 2000 (structure data deposition date)
AuthorsVogt, J. / Perozzo, R. / Pautsch, A. / Prota, A. / Schelling, P. / Pilger, B. / Folkers, G. / Scapozza, L. / Schulz, G.E.
External linksProteins: Struct. ,Funct. , Genet. / PubMed:11056041
MethodsX-ray diffraction
Resolution1.9 - 2.5 Å
Structure data

PDB-1e2h:
The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-1e2i:
The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-1e2j:
The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-APS:
9-HYDROXYPROPYLADENINE, S-ISOMER

ChemComp-ARP:
9-HYDROXYPROPYLADENINE, R-ISOMER

ChemComp-THM:
THYMIDINE

Source
  • herpes simplex virus (type 1 / strain 17)
  • herpes simplex virus (type 1/strain 17)
KeywordsTRANSFERASE / ADENINE ANALOG / ENZYME-PRODRUG GENE THERAPY / NUCLEOSIDE- BINDING / THYMIDINE KINASE

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