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TitleHigh resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA.
Journal, issue, pagesJ. Mol. Biol., Vol. 272, Page 237-252, Year 1997
Publish dateMay 8, 1997 (structure data deposition date)
AuthorsEis, P.S. / Smith, J.A. / Rydzewski, J.M. / Case, D.A. / Boger, D.L. / Chazin, W.J.
External linksJ. Mol. Biol. / PubMed:9299351
MethodsNMR (solution)
Structure data

PDB-1dsa:
(+)-DUOCARMYCIN SA COVALENTLY LINKED TO DUPLEX DNA, NMR, 20 STRUCTURES
Method: SOLUTION NMR

Chemicals

ChemComp-DSA:
4-HYDROXY-8-METHYL-6-(4,5,6-TRIMETHOXY-1H-INDOLE-2-CARBONYL)-3,6,7,8-TETRAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC

KeywordsDNA / DUOCARMYCIN / MINOR GROOVE BINDING / ANTITUMOR AGENT / DRUG-DNA COMPLEX / DEOXYRIBONUCLEIC ACID

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