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TitleMethotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers.
Journal, issue, pagesJ. Biol. Chem., Vol. 270, Page 5057-5064, Year 1995
Publish dateJan 25, 1995 (structure data deposition date)
AuthorsLewis, W.S. / Cody, V. / Galitsky, N. / Luft, J.R. / Pangborn, W. / Chunduru, S.K. / Spencer, H.T. / Appleman, J.R. / Blakley, R.L.
External linksJ. Biol. Chem. / PubMed:7890613
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-1dlr:
METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1dls:
METHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-MXA:
6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE

ChemComp-HOH:
WATER

ChemComp-MTX:
METHOTREXATE / chemotherapy*YM

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / OXIDO-REDUCTASE

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