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TitleAcridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamides.
Journal, issue, pagesMol. Pharmacol., Vol. 58, Page 649-658, Year 2000
Publish dateDec 8, 1999 (structure data deposition date)
AuthorsAdams, A. / Guss, J.M. / Collyer, C.A. / Denny, W.A. / Prakash, A.S. / Wakelin, L.P.
External linksPubMed:10953060
MethodsX-ray diffraction
Resolution1.55 Å
Structure data

PDB-1dl8:
CRYSTAL STRUCTURE OF 5-F-9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE BOUND TO D(CGTACG)2
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-DA7:
5-FLUORO-9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE

ChemComp-HOH:
WATER

KeywordsDNA / INTERCALATION / ACRIDINE

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