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Structure paper

TitleStructures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Journal, issue, pagesStructure Fold. Des., Vol. 8, Page 25-33, Year 2000
Publish dateSep 29, 1999 (structure data deposition date)
AuthorsLiu, S. / Neidhardt, E.A. / Grossman, T.H. / Ocain, T. / Clardy, J.
External linksStructure Fold. Des. / PubMed:10673429
MethodsX-ray diffraction
Resolution1.6 - 1.8 Å
Structure data

PDB-1d3g:
HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-1d3h:
HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH ANTIPROLIFERATIVE AGENT A771726
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-ACT:
ACETATE ION

ChemComp-BRE:
2-BIPHENYL-4-YL-6-FLUORO-3-METHYL-QUINOLINE-4-CARBOXYLIC ACID

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

ChemComp-ORO:
OROTIC ACID

ChemComp-DDQ:
DECYLAMINE-N,N-DIMETHYL-N-OXIDE

ChemComp-HOH:
WATER

ChemComp-A26:
(2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide / medication*YM

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / PROTEIN-ANTIPROLIFERATIVE AGENT COMPLEX / ALPHA-BETA BARREL / MEMBRANE BINDING MOTIF

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