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Structure paper

TitleMolecular basis for P-site inhibition of adenylyl cyclase.
Journal, issue, pagesBiochemistry, Vol. 39, Page 14464-14471, Year 2000
Publish dateAug 16, 1999 (structure data deposition date)
AuthorsTesmer, J.J. / Dessauer, C.W. / Sunahara, R.K. / Murray, L.D. / Johnson, R.A. / Gilman, A.G. / Sprang, S.R.
External linksBiochemistry / PubMed:11087399
MethodsX-ray diffraction
Resolution2.4 - 2.5 Å
Structure data

PDB-1cs4:
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1cul:
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2',5'-DIDEOXY-ADENOSINE 3'-TRIPHOSPHATE AND MG
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-FOK:
FORSKOLIN

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-POP:
PYROPHOSPHATE 2-

ChemComp-101:
2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE

ChemComp-CL:
Unknown entry

ChemComp-GSP:
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

ChemComp-HOH:
WATER

ChemComp-3PO:
TRIPHOSPHATE

ChemComp-103:
2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE

Source
  • canis lupus familiaris (dog)
  • rattus norvegicus (Norway rat)
  • bos taurus (domestic cattle)
KeywordsLYASE/LYASE/SIGNALING PROTEIN / COMPLEX (LYASE-HYDROLASE) / HYDROLASE / SIGNAL TRANSDUCING PROTEIN / CYCLASE / EFFECTOR ENZYME / LYASE-HYDROLASE COMPLEX / LYASE-LYASE-SIGNALING PROTEIN COMPLEX

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