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TitleEffectors of the stringent response target the active site of Escherichia coli adenylosuccinate synthetase.
Journal, issue, pagesJ. Biol. Chem., Vol. 274, Page 17505-17510, Year 1999
Publish dateMar 31, 1999 (structure data deposition date)
AuthorsHou, Z. / Cashel, M. / Fromm, H.J. / Honzatko, R.B.
External linksJ. Biol. Chem. / PubMed:10364182
MethodsX-ray diffraction
Resolution2.3 - 2.5 Å
Structure data

PDB-1ch8:
STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI COMPLEXED WITH A STRINGENT EFFECTOR, PPG2':3'P
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1cib:
STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI COMPLEXED WITH GDP, IMP, HADACIDIN, AND NO3
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NO3:
NITRATE ION

ChemComp-MG:
Unknown entry

ChemComp-GPX:
GUANOSINE 5'-DIPHOSPHATE 2':3'-CYCLIC MONOPHOSPHATE

ChemComp-HDA:
HADACIDIN / anticancer, medication*YM

ChemComp-IMP:
INOSINIC ACID

ChemComp-HOH:
WATER

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

Source
  • escherichia coli (E. coli)
KeywordsLIGASE / ADENYLOSUCCINATE SYNTHETASE / GTP-HYDROLYSING ENZYMES / PURINE 2 NUCLEOTIDE BIOSYNTHESIS / PPGPP / PPG2':3'P / STRINGENT EFFECTOR / GDP

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