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Structure paper

TitleChloroquine binds in the cofactor binding site of Plasmodium falciparum lactate dehydrogenase.
Journal, issue, pagesJ. Biol. Chem., Vol. 274, Page 10213-10218, Year 1999
Publish dateMar 10, 1999 (structure data deposition date)
AuthorsRead, J.A. / Wilkinson, K.W. / Tranter, R. / Sessions, R.B. / Brady, R.L.
External linksJ. Biol. Chem. / PubMed:10187806
MethodsX-ray diffraction
Resolution2 - 2.05 Å
Structure data

PDB-1ceq:
CHLOROQUINE BINDS IN THE COFACTOR BINDING SITE OF PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE.
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1cet:
CHLOROQUINE BINDS IN THE COFACTOR BINDING SITE OF PLASMODIUM FALCIPARUM LACTATE DEHYDROGENASE.
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CLQ:
N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE / medication, antiparasitic*YM

Source
  • plasmodium falciparum (malaria parasite P. falciparum)
KeywordsOXIDOREDUCTASE / TRICARBOXYLIC ACID CYCLE / INHIBITOR

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