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TitleCrystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase.
Journal, issue, pagesBiochemistry, Vol. 38, Page 2367-2376, Year 1999
Publish dateOct 13, 1998 (structure data deposition date)
AuthorsNarayana, N. / Diller, T.C. / Koide, K. / Bunnage, M.E. / Nicolaou, K.C. / Brunton, L.L. / Xuong, N.H. / Ten Eyck, L.F. / Taylor, S.S.
External linksBiochemistry / PubMed:10029530
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-1bx6:
CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-BA1:
BALANOL / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsSERINE/THREONINE-PROTEIN KINASE / BALANOL / CONFORMATIONAL CHANGES / INHIBITION / PROTEIN KINASE PKA / SERINE-THREONINE-PROTEIN KINASE complex

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