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TitleInhibition of the Nmc-A B-Lactamase by a Penicillanic Acid Derivative, and the Structural Bases for the Increase in Substrate Profile of This Antibiotic Resistance Enzyme
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 120, Page 9382-9383, Year 1998
Publish dateSep 4, 1998 (structure data deposition date)
AuthorsMourey, L. / Swaren, P. / Miyashita, K. / Bulychev, A. / Mobashery, S. / Samama, J.P.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.89 Å
Structure data

PDB-1bul:
6ALPHA-(HYDROXYPROPYL)PENICILLANATE ACYLATED ON NMC-A BETA-LACTAMASE FROM ENTEROBACTER CLOACAE
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

Chemicals

ChemComp-AP3:
2-(1-CARBOXY-2-HYDROXY-2-METHYL-PROPYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • enterobacter cloacae (bacteria)
KeywordsHYDROLASE / ANTIBIOTIC RESISTANCE / CLASS A CARBAPENEMASE

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