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TitleUse of X-Ray Co-Crystal Structures and Molecular Modeling to Design Potent and Selective Non-Peptide Inhibitors of Cathepsin K
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 120, Page 9114-, Year 1998
Publish dateMay 29, 1998 (structure data deposition date)
AuthorsDesjarlais, R.L. / Yamashita, D.S. / Oh, H.J. / Uzinskas, I.N. / Erhard, K.F. / Allen, A.C. / Haltiwanger, R.C. / Zhao, B.G. / Smith, W.W. / Abdel-Meguid, S.S. ...Desjarlais, R.L. / Yamashita, D.S. / Oh, H.J. / Uzinskas, I.N. / Erhard, K.F. / Allen, A.C. / Haltiwanger, R.C. / Zhao, B.G. / Smith, W.W. / Abdel-Meguid, S.S. / Dalessio, K. / Janson, C.A. / Mcqueney, M.S. / Tomaszek, T.A. / Levy, M.A. / Veber, D.F.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-1bgo:
CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-I10:
1-[2-(3-BIPHENYL)-4-METHYLVALERYL)]AMINO-3-(2-PYRIDYLSULFONYL)AMINO-2-PROPANONE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / SULFHYDRYL PROTEINASE / THIOL PROTEASE

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