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-Structure paper
Title | Design of potent and selective human cathepsin K inhibitors that span the active site. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 94, Page 14249-14254, Year 1997 |
Publish date | Nov 10, 1997 (structure data deposition date) |
![]() | Thompson, S.K. / Halbert, S.M. / Bossard, M.J. / Tomaszek, T.A. / Levy, M.A. / Zhao, B. / Smith, W.W. / Abdel-Meguid, S.S. / Janson, C.A. / D'Alessio, K.J. ...Thompson, S.K. / Halbert, S.M. / Bossard, M.J. / Tomaszek, T.A. / Levy, M.A. / Zhao, B. / Smith, W.W. / Abdel-Meguid, S.S. / Janson, C.A. / D'Alessio, K.J. / McQueney, M.S. / Amegadzie, B.Y. / Hanning, C.R. / DesJarlais, R.L. / Briand, J. / Sarkar, S.K. / Huddleston, M.J. / Ijames, C.F. / Carr, S.A. / Garnes, K.T. / Shu, A. / Heys, J.R. / Bradbeer, J. / Zembryki, D. / Lee-Rykaczewski, L. / James, I.E. / Lark, M.W. / Drake, F.H. / Gowen, M. / Gleason, J.G. / Veber, D.F. |
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Methods | X-ray diffraction |
Resolution | 2.2 - 2.4 Å |
Structure data | ![]() PDB-1ayu: ![]() PDB-1ayv: ![]() PDB-1ayw: |
Chemicals | ![]() ChemComp-INA: ![]() ChemComp-HOH: ![]() ChemComp-IN6: ![]() ChemComp-IN3: |
Source |
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![]() | HYDROLASE / SULFHYDRYL PROTEINASE |