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Structure paper

TitleCrystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase.
Journal, issue, pagesNat. Struct. Biol., Vol. 4, Page 490-497, Year 1997
Publish dateMay 14, 1997 (structure data deposition date)
AuthorsAchari, A. / Somers, D.O. / Champness, J.N. / Bryant, P.K. / Rosemond, J. / Stammers, D.K.
External linksNat. Struct. Biol. / PubMed:9187658
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1aj0:
CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI DIHYDROPTEROATE SYNTHASE
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1aj2:
CRYSTAL STRUCTURE OF A BINARY COMPLEX OF E. COLI DIHYDROPTEROATE SYNTHASE
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1ajz:
STRUCTURE OF DIHYDROPTEROATE PYROPHOSPHORYLASE
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-PH2:
2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE

ChemComp-SAN:
SULFANILAMIDE / antibiotic*YM

ChemComp-HOH:
WATER

ChemComp-2PH:
[7,8-DIHYDRO-PTERIN-6-YL METHANYL]-PHOSPHONOPHOSPHATE

Source
  • escherichia coli (E. coli)
KeywordsSYNTHASE / ANTIBIOTIC / RESISTANCE / TRANSFERASE / FOLATE / BIOSYNTHESIS

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