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-Structure paper
Title | Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B. |
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Journal, issue, pages | J. Med. Chem., Vol. 41, Page 798-807, Year 1998 |
Publish date | Jan 29, 1998 (structure data deposition date) |
Authors | Taylor, N.R. / Cleasby, A. / Singh, O. / Skarzynski, T. / Wonacott, A.J. / Smith, P.W. / Sollis, S.L. / Howes, P.D. / Cherry, P.C. / Bethell, R. ...Taylor, N.R. / Cleasby, A. / Singh, O. / Skarzynski, T. / Wonacott, A.J. / Smith, P.W. / Sollis, S.L. / Howes, P.D. / Cherry, P.C. / Bethell, R. / Colman, P. / Varghese, J. |
External links | J. Med. Chem. / PubMed:9526556 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.2 Å |
Structure data | PDB-1a4g: PDB-1a4q: PDB-1bji: |
Chemicals | ChemComp-NAG: ChemComp-CA: ChemComp-ZMR: ChemComp-HOH: ChemComp-DPC: ChemComp-MAN: |
Source |
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Keywords | HYDROLASE / GLYCOSIDASE / GLYCOSYLATED PROTEIN / NEURAMINIDASE / INFLUENZA PROTEIN / INHIBITOR COMPLEX / 6-CARBOXAMIDE DERIVATIVE / SIALIC ACID ANALOGUE / GLAXO GR217029 / GLYCOPROTEIN |