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TitleNew insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK.
Journal, issue, pagesStructure, Vol. 5, Page 1681-1693, Year 1997
Publish dateNov 30, 1997 (structure data deposition date)
AuthorsMartin, P.D. / Malkowski, M.G. / Box, J. / Esmon, C.T. / Edwards, B.F.
External linksStructure / PubMed:9438869
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-1a0h:
THE X-RAY CRYSTAL STRUCTURE OF PPACK-MEIZOTHROMBIN DESF1: KRINGLE/THROMBIN AND CARBOHYDRATE/KRINGLE/THROMBIN INTERACTIONS AND LOCATION OF THE LINKER CHAIN
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-0G6:
D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide

ChemComp-HOH:
WATER

Source
  • bos taurus (cattle)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / SERINE PROTEASE / COAGULATION / THROMBIN / PROTHROMBIN / MEIZOTHROMBIN / HYDROLASE-HYDROLASE INHIBITOR COMPLEX

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