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TitleStructural heterogeneity of CTE Type I tau filaments with an interface-shifted polymorph.
Journal, issue, pagesBiochem Biophys Res Commun, Vol. 838, Page 154679, Year 2026
Publish dateOct 1, 2026
AuthorsRyohei Watanabe / Edward B Lee /
PubMed AbstractTau filament types can differ in inter-protofilament packing while sharing the same protofilament fold. Motivated by our recent findings in vacuolar tauopathy, we analyzed cryo-electron microscopy ...Tau filament types can differ in inter-protofilament packing while sharing the same protofilament fold. Motivated by our recent findings in vacuolar tauopathy, we analyzed cryo-electron microscopy (cryo-EM) data from brain-derived chronic traumatic encephalopathy (CTE) tau filaments deposited in EMPIAR-10313. We resolved the canonical CTE Type I structure and a previously unreported CTE Type I-like structure with a shifted protofilament interface at 2.78 and 2.96 Å, respectively. Mapping particle-state assignments back onto the original micrographs showed that the CTE Type I and CTE Type I-like packing states can occupy locally contiguous regions within the same fibrils. These findings identify an interface-shifted CTE Type I-like structure and support its local coexistence with CTE Type I within individual fibrils.
External linksBiochem Biophys Res Commun / PubMed:42826653
MethodsEM (helical sym.)
Resolution2.78 - 2.96 Å
Structure data

78521

37vx

EMDB-78521: CTE Type I
PDB-37vx: CTE Type I structure
Method: EM (helical sym.) / Resolution: 2.78 Å

78522

37vy

EMDB-78522: CTE Type I-like
PDB-37vy: CTE Type I-like structure
Method: EM (helical sym.) / Resolution: 2.96 Å

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / Microtubule-associated protein

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