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TitleIn-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association
Journal, issue, pagesTo Be Published
Publish dateMay 27, 2026 (structure data deposition date)
AuthorsBasiashvili T / Villa E
External linksSearch PubMed
MethodsEM (subtomogram averaging)
Resolution13.5 - 24.5 Å
Structure data

EMDB-77327: Focused map of the COR:COR interaction interface in microtubule-associated LRRK2 I2020T filaments formed in the presence of MLi-2
Method: EM (subtomogram averaging) / Resolution: 13.5 Å

EMDB-77329: Focused map of four central LRRK2 I2020T units in the microtubule-associated filament lattice formed in the presence of MLi-2
Method: EM (subtomogram averaging) / Resolution: 24.5 Å

EMDB-77330: Microtubule-associated LRRK2 I2020T filaments in HEK293T cells treated with GZD-824
Method: EM (subtomogram averaging) / Resolution: 17.0 Å

Source
  • Homo sapiens (human)

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