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TitleLipid droplets promote the aberrant liquid-liquid phase separation of alpha-synuclein leading to impaired energy homeostasis
Journal, issue, pagesTo Be Published
Publish dateApr 30, 2026 (structure data deposition date)
AuthorsCevallos J / Eubanks E / Jung S / Huang Y / Guadagno E / Jaber N / Xia Y / Wang J / Wang H / Suvvari NR ...Cevallos J / Eubanks E / Jung S / Huang Y / Guadagno E / Jaber N / Xia Y / Wang J / Wang H / Suvvari NR / Doshi A / Ravinutala N / Mosera A / Hsu T / Mody J / Sacks B / Narayan A / Smith B / Wang M / Gottapu M / Ramalingam N / Tripathi A / Bartels T / Dettmer U / Shi Z / Dai W / Kara E
External linksSearch PubMed
MethodsEM (tomography)
Structure data

EMDB-76979: Cryo-ET of mitochondrial membrane in direct interaction with alpha-synuclein exhibiting membrane morphological distortion
Method: EM (tomography)

EMDB-76980: Supplemental: irregularly shaped mitochondria interacting with alpha-synuclein
Method: EM (tomography)

EMDB-76981: Supplemental: alpha-synuclein oligomers on the surface of a mitochondrial membrane
Method: EM (tomography)

EMDB-76983: Supplemental: mitochondria not associated with alpha-synuclein
Method: EM (tomography)

Source
  • Homo sapiens (human)

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