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TitleBroadly cross-reactive anti-capsid IgA is an overlooked antibody 1 barrier in AAV2 mediated gene transfer
Journal, issue, pagesNat Commun, Year 2026
Publish dateApr 20, 2026 (structure data deposition date)
AuthorsLogan GJ / Khandekar N / Hall B / Zachery J / Mandwie M / Hsi-Bell J / Huang A / Vyas K / Anderson D / Knight M ...Logan GJ / Khandekar N / Hall B / Zachery J / Mandwie M / Hsi-Bell J / Huang A / Vyas K / Anderson D / Knight M / Farrar MA / Lisowski L / Reed JH / Mietzsch M / McKenna R / Alexander IE
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.48 - 3.28 Å
Structure data

76770

12us

EMDB-76770, PDB-12us:
The AAV2 capsid in complex with IgG-Fab#3-2
Method: EM (single particle) / Resolution: 3.28 Å

76771

12ut

EMDB-76771, PDB-12ut:
The AAV2 capsid in complex with IgA-Fab#3-2
Method: EM (single particle) / Resolution: 2.48 Å

76772

12uu

EMDB-76772, PDB-12uu:
The AAV2 capsid in complex with IgG-Fab#3-4
Method: EM (single particle) / Resolution: 2.91 Å

76773

12uv

EMDB-76773, PDB-12uv:
The AAV2 capsid in complex with IgA-Fab#3-4
Method: EM (single particle) / Resolution: 2.68 Å

Source
  • adeno-associated virus 2
  • homo sapiens (human)
KeywordsVIRUS / AAV / gene therapy / antibody / cryo-EM / IgA / Neutralization

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