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-Structure paper
| Title | Tuning of AMPA receptor activation by inhibitory auxiliary subunits and epilepsy-associated disease mutations |
|---|---|
| Journal, issue, pages | Nat Commun, Year 2026 |
| Publish date | Mar 13, 2026 (structure data deposition date) |
Authors | Newton TP / Yelshanskaya MV / Aktolun M / Gangwar SP / Yen LY / Alekseev AA / Sobolevsky IA / Kurnikova MG / Sobolevsky AI |
External links | Nat Commun / Search PubMed |
| Methods | EM (single particle) |
| Resolution | 3.35 - 4.29 Å |
| Structure data | EMDB-76055, PDB-11uf: EMDB-76056, PDB-11ug: EMDB-76057, PDB-11uh: EMDB-76058, PDB-11ui: ![]() EMDB-76059: GluA2 active state + RR2b + Glu (consensus map) ![]() EMDB-76060: GluA2 open state + RR2b + Glu (ATD-LBD only) ![]() EMDB-76061: GluA2 active state + RR2b + Glu (TMD only) |
| Chemicals | ![]() ChemComp-GLU: ![]() ChemComp-FWF: ![]() ChemComp-SPD: |
| Source |
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Keywords | MEMBRANE PROTEIN / ionotropic glutamate receptor (iGluR) / GluA2 / transmembrane AMPAR regulatory protein (TARP) / y5 / cornichon / CNIH1 / GSG1L / iGluR |
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homo sapiens (human)
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