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TitlePreclinical characterization of a reversible XPO1 inhibitor for cancer therapy
Journal, issue, pagesNat Commun, Year 2026
Publish dateMar 10, 2026 (structure data deposition date)
AuthorsVan Hauwenhuyse J / Reniers F / Persoons L / Noppen S / Wing CE / Niesman AB / Fung HYJ / Vanstreels E / Jacquemyn M / Boel E ...Van Hauwenhuyse J / Reniers F / Persoons L / Noppen S / Wing CE / Niesman AB / Fung HYJ / Vanstreels E / Jacquemyn M / Boel E / Vankerckhoven A / Berckmans Y / Kwanten B / Coosemans A / Van den Mooter G / Chook YM / Dehaen W / Daelemans D
External linksNat Commun / Search PubMed
MethodsEM (single particle)
Resolution2.95 Å
Structure data

75979

11rm

EMDB-75979, PDB-11rm:
Cryo-EM structure of human exportin-1 conjugated with FR-027*
Method: EM (single particle) / Resolution: 2.95 Å

Chemicals

PDB-1dbj:
MOLECULAR BASIS OF CROSS-REACTIVITY AND THE LIMITS OF ANTIBODY-ANTIGEN COMPLEMENTARITY

Source
  • homo sapiens (human)
KeywordsPROTEIN TRANSPORT / nuclear transport / inhibitor

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