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TitleClustering and a conformational switch drive activation of the mammalian receptor tyrosine kinase ROS1
Journal, issue, pagesTo Be Published
Publish dateJan 17, 2026 (structure data deposition date)
AuthorsLi H / Klein D
External linksTo Be Published / Search PubMed
MethodsEM (single particle)
Resolution3.06 - 3.21 Å
Structure data

75142

10ft

EMDB-75142, PDB-10ft:
Cryo-EM structure of receptor tyrosine kinase ROS1 in complex with NELL2
Method: EM (single particle) / Resolution: 3.21 Å

75151

10gh

EMDB-75151, PDB-10gh:
Cryo-EM structure of Receptor Tyrosine Kinase ROS1 in complex with Fab-RX5
Method: EM (single particle) / Resolution: 3.06 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsTRANSFERASE / Receptor tyrosine kinase ROS1 / ROS1-NELL2 complex / TRANSFERASE-SIGNALING PROTEIN complex / TRANSFERASE/IMMUNE SYSTEM / Receptor tyrosine kinase / ROS1 extracellular bent-over conformation / Inhibitory Fab-RX5 / TRANSFERASE-IMMUNE SYSTEM complex

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