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TitleStructure-based design of soluble prefusion-stabilized herpes simplex virus type 2 glycoprotein B antigens
Journal, issue, pagesTo Be Published
Publish dateJan 1, 2026 (structure data deposition date)
AuthorsSponholtz MR / Ma D / Byrne PO / Shu Y / Warren C / Thambi N / McCool RS / Slein MD / Johnson NV / Rose WA ...Sponholtz MR / Ma D / Byrne PO / Shu Y / Warren C / Thambi N / McCool RS / Slein MD / Johnson NV / Rose WA / Zhang L / Durr E / Wang D / McLellan JM
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.75 Å
Structure data

74907

9zwe

EMDB-74907, PDB-9zwe:
Soluble ectodomain of Herpes simplex virus 2 (HSV-2) glycoprotein B (gB) in the prefusion conformation in complex with 2c and D48 Fabs
Method: EM (single particle) / Resolution: 2.75 Å

Source
  • Human herpesvirus 2 (strain HG52)
  • human herpesvirus 2 strain hg52
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / prefusion / ectodomain / viral fusion protein / VIRAL PROTEIN-IMMUNE SYSTEM complex

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