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TitleInsight into the scaffolding function of USP18 from a high resolution cryo-EM structure of STAT2-USP18-ISG15 ternary complex
Journal, issue, pagesBiorxiv, Year 2026
Publish dateDec 1, 2025 (structure data deposition date)
AuthorsHuynh KW / Plumb R / Healy DR / Jove V / Ralph EC / Lee CW / Wheeler H / Levine K / Huang Z / Fennell K ...Huynh KW / Plumb R / Healy DR / Jove V / Ralph EC / Lee CW / Wheeler H / Levine K / Huang Z / Fennell K / Corpina RA / Craig T / Wes PD / Loria PM / Schenone M / Han S / Wang F / Wu H / Yamaguchi M
External linksBiorxiv / Search PubMed
MethodsEM (single particle)
Resolution3.05 Å
Structure data

74146

9zfo

EMDB-74146, PDB-9zfo:
Cryo-EM Structure of Human STAT2-USP18-ISG15 Complex
Method: EM (single particle) / Resolution: 3.05 Å

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Deubiquitinating Enzyme / ISGylation / Transcription Factor

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