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-Structure paper
| Title | A universal Fab targeting a conserved U1A-RNA epitope for RNA structure determination by cryo-EM |
|---|---|
| Journal, issue, pages | Nucleic Acids Res., Vol. 54, Year 2026 |
| Publish date | Oct 27, 2025 (structure data deposition date) |
Authors | Filippova EV / Krochmal D / Mukherjee S / Piccirilli JA / Kossiakoff AA |
External links | Nucleic Acids Res. / Search PubMed |
| Methods | EM (single particle) |
| Resolution | 2.9 - 4.32 Å |
| Structure data | EMDB-73618, PDB-9yxv: ![]() EMDB-73655: The global map of cIL-U1A-Fab1R-PGA1-sfFab18 quaternary complex EMDB-73840: Cryo-EM structure of the open state of cIL RNA region at 4.3 A resolution ![]() EMDB-75812: The composite map of cIL-U1A-Fab1R-PGA1-sfFab18 quaternary complex |
| Chemicals | ![]() ChemComp-DMU: |
| Source |
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Keywords | IMMUNE SYSTEM / antibody / Fab / RNA / ribozyme / U1A / ribonucleoprotein (snRNP) complex |
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