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Structure paper

TitleA SARS-CoV-2 entry inhibitor trimerizes to lock the spike trimer in its closed conformation
Journal, issue, pagesTo Be Published
Publish dateOct 23, 2025 (structure data deposition date)
AuthorsMou H / Gao B / Ye G / Bu F / Zhang L / Farzan M / Li F / Choe H
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.66 - 3.15 Å
Structure data

73523

9yvg

EMDB-73523, PDB-9yvg:
Cryo-EM structure of BA.5 spike, Open conformation
Method: EM (single particle) / Resolution: 3.15 Å

73524

9yvh

EMDB-73524, PDB-9yvh:
Cryo-EM structure of BA.5 spike, Closed conformation
Method: EM (single particle) / Resolution: 2.83 Å

73525

9yvi

EMDB-73525, PDB-9yvi:
Cryo-EM structure of BA.5 spike in complex with S22
Method: EM (single particle) / Resolution: 2.66 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

PDB-1czb:
ATOMIC RESOLUTION ASV INTEGRASE CORE DOMAIN FROM HEPES

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN / SARS-CoV-2 / entry

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