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TitleNegative cooperativity drives activity of capsid-directed antivirals against Hepatitis B Virus
Journal, issue, pagesTo Be Published
Publish dateOct 12, 2025 (structure data deposition date)
AuthorsValkner CJ / Gibes NG / Xie MS / Kumar S / Francis S / Venkatakrishnan B / Tsvetkova I / Patterson A / VanNieuwenhze M / Dragnea B ...Valkner CJ / Gibes NG / Xie MS / Kumar S / Francis S / Venkatakrishnan B / Tsvetkova I / Patterson A / VanNieuwenhze M / Dragnea B / Wang JC-Y / Zlotnick A
External linksSearch PubMed
MethodsEM (single particle)
Resolution5.3 - 7.9 Å
Structure data

EMDB-73227: Focused map of HBV with BAY41-4109
Method: EM (single particle) / Resolution: 7.9 Å

EMDB-73229: Focused map of HBV Capsid with compound HAP12
Method: EM (single particle) / Resolution: 5.3 Å

Source
  • Hepatitis B virus
  • Homo sapiens (human)

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