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TitleMechanisms of HSV replisome assembly and targeting by helicase?primase inhibitors
Journal, issue, pagesTo Be Published
Publish dateSep 19, 2025 (structure data deposition date)
AuthorsYu Z / Abraham J
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.55 - 2.8 Å
Structure data

EMDB-72787: Local refinement of HSV UL5 in amenamevir-bound H/P complex
Method: EM (single particle) / Resolution: 2.55 Å

EMDB-72788: Local refinement of HSV UL8 in amenamevir-bound H/P complex
Method: EM (single particle) / Resolution: 2.6 Å

72789

9ycv

EMDB-72789, PDB-9ycv:
HSV Helicase-primase complex bound to amenamevir
Method: EM (single particle) / Resolution: 2.8 Å

Chemicals

ChemComp-ZN:
Unknown entry

PDB-1bxd:
NMR STRUCTURE OF THE HISTIDINE KINASE DOMAIN OF THE E. COLI OSMOSENSOR ENVZ

Source
  • human alphaherpesvirus 1 strain r-15
KeywordsVIRAL PROTEIN / HSV / helicase-primase / HPI

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