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Structure paper

TitleCryo-EM Reveals Regulatory Mechanisms Governing Substrate Selection and Activation of Human LONP1
Journal, issue, pagesElife, Year 2025
Publish dateSep 4, 2025 (structure data deposition date)
AuthorsMindrebo JT / Alexandrescu L / Baker JR / Wang G / Lander GC
External linksElife / Search PubMed
MethodsEM (single particle)
Resolution2.92 - 3.7 Å
Structure data

72513

9y5m

EMDB-72513, PDB-9y5m:
LONP1 C3-state
Method: EM (single particle) / Resolution: 2.92 Å

72514

9y5n

EMDB-72514, PDB-9y5n:
LONP1 C2-state
Method: EM (single particle) / Resolution: 3.35 Å

72515

9y5o

EMDB-72515, PDB-9y5o:
LONP1 C2-state
Method: EM (single particle) / Resolution: 3.47 Å

EMDB-72516: LONP1 Intermediate 3
Method: EM (single particle) / Resolution: 3.44 Å

EMDB-72517: Open form of LONP1, LONP1-OFF
Method: EM (single particle) / Resolution: 3.7 Å

EMDB-72518: LONP1 C3-Like State
Method: EM (single particle) / Resolution: 3.35 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSLOCASE / AAA+ / Lon / LONP1 / protease / Regulatory state

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