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TitleStructure of the lysosomal KICSTOR-GATOR1 nutrient-sensing supercomplex
Journal, issue, pagesTo Be Published
Publish dateAug 28, 2025 (structure data deposition date)
AuthorsBayly-Jones C / Lupton CJ / Chang YG / Ellisdon AM
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.8 - 3.9 Å
Structure data

72378

9xzy

EMDB-72378, PDB-9xzy:
DEPDC5 dimer (tandem DEPDC5) focused map
Method: EM (single particle) / Resolution: 3.8 Å

EMDB-72379: DEPDC5 NPRL2 NPRL3 SZT2 focused refinement
Method: EM (single particle) / Resolution: 3.9 Å

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / Lysosome / GATOR1 / KICSTOR / cell growth / amino acid sensing / mTOR / KPTN / ITFG2 / C12orf66 / SZT2 / NPRL2 / NPRL3 / DEPDC5

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