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TitleSpecies- and variant-specific ACE2 compatibility shapes SARS-CoV-2 spillover potential in North American cervids
Journal, issue, pagesTo Be Published
Publish dateAug 19, 2025 (structure data deposition date)
AuthorsEspada C / Ye K / Long Y / Pasai K / DeLiberto TJ / Heale J / Wiese R / Yang Q / Zhou M / Streich S ...Espada C / Ye K / Long Y / Pasai K / DeLiberto TJ / Heale J / Wiese R / Yang Q / Zhou M / Streich S / Tao YJ / Chandler JC / Wan XF
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.3 - 3.37 Å
Structure data

72207

9q3u

EMDB-72207, PDB-9q3u:
Cryo EM structure of elk ACE2 in complex with SARS-CoV-2 spike trimer
Method: EM (single particle) / Resolution: 3.37 Å

72208

9q3v

EMDB-72208, PDB-9q3v:
Cryo EM structure of elk ACE2 in complex with XBB 1.5 spike RBD
Method: EM (single particle) / Resolution: 3.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • severe acute respiratory syndrome coronavirus 2
  • cervus canadensis (elk)
  • Severe acute respiratory syndrome coronavirus
KeywordsVIRAL PROTEIN / SARS-CoV-2 / Cervidae / ACE2 receptor / viral host interaction / host susceptibility

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