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TitleA biased allosteric modulator is a molecular glue for Beta2AR dimerization
Journal, issue, pagesTo Be Published
Publish dateAug 18, 2025 (structure data deposition date)
AuthorsShen J / Peddada TN / Jun X / Kobilka BK
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.5 Å
Structure data

72202

9q3l

EMDB-72202, PDB-9q3l:
CryoEM structure of beta2-adrenergic receptor dimer mediated by a biased allosteric modulator in lipid nanodisc
Method: EM (single particle) / Resolution: 2.5 Å

Chemicals

ChemComp-C14:
TETRADECANE

ChemComp-LFA:
EICOSANE

ChemComp-P0G:
8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one

PDB-1cns:
CRYSTAL STRUCTURE OF CHITINASE AT 1.91A RESOLUTION

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / GPCR / Adrenergic receptor / Dimer / Molecular glue / Biased allosteric modulator

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