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TitleGenetically protective human EBV-neutralizing mAbs targeting multiple receptor-binding sites mAbs elicited in transgenic mice
Journal, issue, pagesTo Be Published
Publish dateJul 3, 2025 (structure data deposition date)
AuthorsChan CB / Lang K / Davis AR / Wan YH / Aldridge NT / Kher G / Scharffenberger SC / Hardy SR / Iureniev R / Giltiay NV ...Chan CB / Lang K / Davis AR / Wan YH / Aldridge NT / Kher G / Scharffenberger SC / Hardy SR / Iureniev R / Giltiay NV / Edwards KR / Radtke S / Kiem HP / Pancera M / McGuire A
External linksSearch PubMed
MethodsEM (single particle)
Resolution6.69 - 16.16 Å
Structure data

EMDB-71587: Negative stain EM map of EBV glycoprotein gH/gL in complex with glycoprotein gp42 and FAB ATX-42-1.1 partially open conformation
Method: EM (single particle) / Resolution: 16.16 Å

EMDB-71588: Negative stain EM map of EBV glycoprotein gH/gL in complex with glycoprotein gp42 and FAB ATX-42-2 closed conformation
Method: EM (single particle) / Resolution: 11.6 Å

EMDB-71589: Negative stain EM map of EBV glycoprotein gH/gL in complex with glycoprotein gp42 and HLA-DR1 Beta chain
Method: EM (single particle) / Resolution: 11.62 Å

EMDB-71590: Negative Stain EM map of EBV glycoprotein gp350 in complex with ATX-350-1 FAB and 72A1 FAB
Method: EM (single particle) / Resolution: 6.69 Å

EMDB-71592: Negative Stain EM map of EBV glycoprotein gp350 in complex with ATX-350-2 FAB
Method: EM (single particle) / Resolution: 7.67 Å

EMDB-71593: Negative Stain EM map of EBV glycoprotein gp350 in complex with ATX-350-1 FAB
Method: EM (single particle) / Resolution: 12.84 Å

EMDB-71594: Negative Stain EM map of EBV glycoprotein gp350 in complex with 72A1 FAB
Method: EM (single particle) / Resolution: 9.88 Å

Source
  • human gammaherpesvirus 4 (Epstein-Barr virus)
  • Mus musculus (house mouse)
  • Homo sapiens (human)

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