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TitleStructural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramer.
Journal, issue, pagesNat Commun, Year 2025
Publish dateDec 16, 2025
AuthorsHui Zhang / Xiao-Chen Bai / Xuewu Zhang /
PubMed AbstractThe IL-17 receptors (IL-17Rs) play critical roles in immunity and inflammatory diseases. IL-17-induced heteromeric complexes between IL-17RA and another IL-17R trigger signaling by binding the ...The IL-17 receptors (IL-17Rs) play critical roles in immunity and inflammatory diseases. IL-17-induced heteromeric complexes between IL-17RA and another IL-17R trigger signaling by binding the downstream transducer ACT1 through interactions between their intracellular SEF/IL-17R (SEFIR) domains. The molecular mechanism of this process remains unclear. Here we present the cryo-EM structure of the complex of IL-17RA, IL-17RB and ACT1, showing that the IL-17RA and IL-17RB SEFIR domains form an asymmetric hetero-tetramer. The two IL-17RA SEFIR domains serve as the base to recruit ACT1, while IL-17RB stabilizes the IL-17RA dimer but makes no interaction with ACT1. IL-17RB, IL-17RA, and multiple ACT1 together form a double-stranded helical assembly. The C-terminal SEFIR extension (SEFEX) of IL-17RA acts as a molecular tendril to help anchor the ACT1 protomers. The structural model is supported by our mutational analyses. These findings reveal the basis for the formation for the signalosome of the IL-17 receptors and ACT1 critical for immune signaling.
External linksNat Commun / PubMed:41397964
MethodsEM (single particle) / EM (helical sym.)
Resolution3.0 - 3.3 Å
Structure data

EMDB-70814: Helical assembly of the IL-17RA/RB/ACT1 complex consensus map
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-70816: Helical assembly of the IL-17RA/RB/ACT1 complex lower part focused map
Method: EM (single particle) / Resolution: 3.0 Å

EMDB-70817: Helical reconstruction of the IL-17RA/RB/ACT1 complex
Method: EM (helical sym.) / Resolution: 3.3 Å

70818

9ot1

EMDB-70818, PDB-9ot1:
Helical assembly of the IL-17RA/RB/ACT1 complex
Method: EM (single particle) / Resolution: 3.0 Å

Chemicals

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / IL-17 receptor / ACT1 / helical assembly / IL-17

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