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TitleMultiscale structure of chromatin condensates explains phase separation and material properties.
Journal, issue, pagesScience, Vol. 390, Issue 6777, Page eadv6588, Year 2025
Publish dateDec 4, 2025
AuthorsHuabin Zhou / Jan Huertas / M Julia Maristany / Kieran Russell / June Ho Hwang / Run-Wen Yao / Nirnay Samanta / Joshua Hutchings / Ramya Billur / Momoko Shiozaki / Xiaowei Zhao / Lynda K Doolittle / Bryan A Gibson / Andrea Soranno / Margot Riggi / Jorge R Espinosa / Zhiheng Yu / Elizabeth Villa / Rosana Collepardo-Guevara / Michael K Rosen /
PubMed AbstractThe structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo-electron tomography and molecular dynamics simulations, we elucidated the ...The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo-electron tomography and molecular dynamics simulations, we elucidated the structure of phase-separated chromatin condensates across scales, from individual amino acids to network architecture. We found that internucleosomal DNA linker length controls nucleosome arrangement and histone tail interactions, shaping the structure of individual chromatin molecules within and outside condensates. This structural modulation determines the balance between intra- and intermolecular interactions, which governs the molecular network, thermodynamic stability, and material properties of chromatin condensates. Mammalian nuclei contain dense clusters of nucleosomes whose nonrandom organization is mirrored by the reconstituted condensates. Our work explains how the structure of individual chromatin molecules determines physical properties of chromatin condensates and cellular chromatin organization.
External linksScience / PubMed:41343645 / PubMed Central
MethodsEM (subtomogram averaging)
Resolution5.8 - 8.0 Å
Structure data

EMDB-70743: Nucleosome subtomogram average from chromatin droplets reconstituted with 30 bp linker DNA
Method: EM (subtomogram averaging) / Resolution: 5.8 Å

EMDB-70745: Nucleosome subtomogram average from chromatin droplets reconstituted with 25 bp linker DNA
Method: EM (subtomogram averaging) / Resolution: 8.0 Å

Source
  • Escherichia coli (E. coli)

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