[English] 日本語
Yorodumi Papers
- Database of articles cited by EMDB/PDB/SASBDB data -

+
Search query

Keywords
Structure methods
Author
Journal
IF

-
Structure paper

TitleVaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial.
Journal, issue, pagesSci Transl Med, Vol. 17, Issue 809, Page eady6831, Year 2025
Publish dateJul 30, 2025
AuthorsK Rachael Parks / Zoe Moodie / Mary A Allen / Catherine Yen / Briana D Furch / Kellie J MacPhee / Gabriel Ozorowski / Jack Heptinstall / William O Hahn / Zihan Zheng / Huiyin Lu / Shannon Grant / Elize Domin / Michael O Duff / Aaron Seese / Constanza Marini-Macouzet / Lamar Ballweber-Fleming / Wen-Hsin Lee / Christopher A Cottrell / Alessia Liguori / Erik Georgeson / Nushin Alavi / Michael Kubitz / Nicole Phelps / Kelly E Seaton / Kristen W Cohen / Maija A Anderson / Kajari Mondal / Dagna S Laufer / James G Kublin / Andrew B Ward / Ollivier Hyrien / Stephen C De Rosa / Sunny Himansu / Brett Leav / Caroline Reuter / Georgia D Tomaras / David Montefiori / Stephen R Walsh / Ian Frank / Magdalena E Sobieszczyk / Paul A Goepfert / Kathryn E Stephenson / Lindsey R Baden / Hong Van Tieu / Michael C Keefer / Jesse Clark / Sharon A Riddler / William R Schief / M Juliana McElrath /
PubMed AbstractmRNA technology might accelerate development of an urgently needed preventive human immunodeficiency virus (HIV) vaccine. We evaluated the safety and immunogenicity of three mRNA-encoded envelope ...mRNA technology might accelerate development of an urgently needed preventive human immunodeficiency virus (HIV) vaccine. We evaluated the safety and immunogenicity of three mRNA-encoded envelope trimers, including two doses of soluble and membrane-anchored forms, in a randomized, open-label, phase 1 clinical trial. Vaccines were generally well tolerated, although 6.5% (7 of 108) of participants developed urticaria, a higher proportion than seen with other mRNA vaccines. mRNA-encoded trimers induced strong envelope-specific B and T cell responses. Immunization with membrane-anchored trimers, intended to obscure epitopes at the trimer base targeted by nonneutralizing antibodies, reduced the frequency of base-binding serum antibodies in comparison with soluble trimers. Three immunizations elicited autologous tier 2 serum neutralizing antibodies in 80% of vaccinees receiving the membrane-anchored trimers, in contrast to only 4% receiving the soluble trimer. Thus, with demonstration of more favorable safety, mRNA-encoded membrane-anchored HIV envelope trimers represent a promising platform for HIV vaccine clinical development.
External linksSci Transl Med / PubMed:40737434 / PubMed Central
MethodsEM (single particle)
Resolution26.0 - 30.0 Å
Structure data

EMDB-70340: FH_302_07 Fab in complex with BG505 MD39.3 SOSIP (negative stain)
Method: EM (single particle) / Resolution: 30.0 Å

EMDB-70341: FH_302_14 Fab in complex with BG505 MD39.3 SOSIP (negative stain)
Method: EM (single particle) / Resolution: 26.0 Å

EMDB-70342: FH_302_23 Fab in complex with BG505 MD39.3 SOSIP (negative stain)
Method: EM (single particle) / Resolution: 26.0 Å

EMDB-70343: BG505 MD39.3-CC5 SOSIP in complex with V1V3 epitope polyclonal Fabs isolated from HVTN302 human trial after dose 3 of mRNA-gp151-CD4KO immunization
Method: EM (single particle) / Resolution: 28.0 Å

EMDB-70344: BG505 MD39.3-CC5 SOSIP in complex with gp41-base epitope polyclonal Fabs isolated from HVTN302 human trial after dose 3 of mRNA-gp151-CD4KO immunization
Method: EM (single particle) / Resolution: 26.0 Å

EMDB-70345: BG505 MD39.3-CC5 SOSIP in complex with C3V5 epitope polyclonal Fabs isolated from HVTN302 human trial after dose 3 of mRNA-gp151-CD4KO immunization
Method: EM (single particle) / Resolution: 28.0 Å

Source
  • Human immunodeficiency virus 1

+
About Yorodumi Papers

-
News

-
Feb 9, 2022. New format data for meta-information of EMDB entries

New format data for meta-information of EMDB entries

  • Version 3 of the EMDB header file is now the official format.
  • The previous official version 1.9 will be removed from the archive.

Related info.:EMDB header

External links:wwPDB to switch to version 3 of the EMDB data model

-
Aug 12, 2020. Covid-19 info

Covid-19 info

URL: https://pdbj.org/emnavi/covid19.php

New page: Covid-19 featured information page in EM Navigator.

Related info.:Covid-19 info / Mar 5, 2020. Novel coronavirus structure data

+
Mar 5, 2020. Novel coronavirus structure data

Novel coronavirus structure data

Related info.:Yorodumi Speices / Aug 12, 2020. Covid-19 info

External links:COVID-19 featured content - PDBj / Molecule of the Month (242)：Coronavirus Proteases

+
Jan 31, 2019. EMDB accession codes are about to change! (news from PDBe EMDB page)

EMDB accession codes are about to change! (news from PDBe EMDB page)

  • The allocation of 4 digits for EMDB accession codes will soon come to an end. Whilst these codes will remain in use, new EMDB accession codes will include an additional digit and will expand incrementally as the available range of codes is exhausted. The current 4-digit format prefixed with “EMD-” (i.e. EMD-XXXX) will advance to a 5-digit format (i.e. EMD-XXXXX), and so on. It is currently estimated that the 4-digit codes will be depleted around Spring 2019, at which point the 5-digit format will come into force.
  • The EM Navigator/Yorodumi systems omit the EMD- prefix.

Related info.:Q: What is EMD? / ID/Accession-code notation in Yorodumi/EM Navigator

External links:EMDB Accession Codes are Changing Soon! / Contact to PDBj

+
Jul 12, 2017. Major update of PDB

Major update of PDB

  • wwPDB released updated PDB data conforming to the new PDBx/mmCIF dictionary.
  • This is a major update changing the version number from 4 to 5, and with Remediation, in which all the entries are updated.
  • In this update, many items about electron microscopy experimental information are reorganized (e.g. em_software).
  • Now, EM Navigator and Yorodumi are based on the updated data.

External links:wwPDB Remediation / Enriched Model Files Conforming to OneDep Data Standards Now Available in the PDB FTP Archive

-
Yorodumi Papers

Database of articles cited by EMDB/PDB/SASBDB data

  • Database of articles cited by EMDB, PDB, and SASBDB entries
  • Using PubMed data

Related info.:EMDB / PDB / SASBDB / Yorodumi / EMN Papers / Changes in new EM Navigator and Yorodumi

Read more