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Structure paper

TitleMolecular mechanism of action of menthol, a novel inhibitor of TRPV5 channels
Journal, issue, pagesTo Be Published
Publish dateApr 13, 2025 (structure data deposition date)
AuthorsMendez-Resendiz A / De Jesus-Perez JJ / Rangel-Yescas GE / Rosenbaum T / Moiseenkova-Bell VY / Islas DL
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.37 Å
Structure data

70173

9o6g

EMDB-70173, PDB-9o6g:
Wildtype rabbit TRPV5 in nanodics in the presence of Menthol and PI(4,5)P2
Method: EM (single particle) / Resolution: 3.37 Å

Chemicals

ChemComp-ERG:
ERGOSTEROL

ChemComp-CPL:
1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE / phospholipid*YM

ChemComp-PIO:
[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate

ChemComp-IT9:
(-)-Isopiperitenone

Source
  • oryctolagus cuniculus (rabbit)
KeywordsMEMBRANE PROTEIN / TRPV5 / TRP Channel / Menthol / PI(4 / 5)P2

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