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TitleHuman monoclonal antibodies that target the SFTSV glycoprotein Gn head from four neutralizing epitope groups.
Journal, issue, pagesCell Rep, Vol. 45, Issue 4, Page 117248, Year 2026
Publish dateApr 8, 2026
AuthorsQianran Wang / Hao Li / Fanchong Jian / Aoxiang Han / Yuanni Liu / Jingyi Liu / Yuanling Yu / Jing Wang / Lingling Yu / Yanxia Wang / Haiyan Sun / Miaomiao Ma / Fei Shao / Liuluan Zhu / Wei Liu / Yunlong Cao /
PubMed AbstractSevere fever with thrombocytopenia syndrome virus (SFTSV) is a lethal bunyavirus lacking approved countermeasures. From SFTS survivors, we isolate 84 human monoclonal antibodies (mAbs) against the ...Severe fever with thrombocytopenia syndrome virus (SFTSV) is a lethal bunyavirus lacking approved countermeasures. From SFTS survivors, we isolate 84 human monoclonal antibodies (mAbs) against the viral glycoproteins Gn and Gc. Gn-specific mAbs demonstrate superior neutralization breadth and potency compared to the restricted neutralizing activity observed with Gc. Using a high-throughput yeast display deep mutational scanning (DMS) platform, we classify Gn-head mAbs into eight epitope groups, among which four groups (IA, ID, IIIA, and IIIB) confer neutralization. Notably, mAbs BD70-4003 (group IA) and BD70-4017 (group IIIA) exhibit broad neutralization and provide 100% protection in a lethal mouse model. Cryo-electron microscopy (cryo-EM) structural analysis of these mAbs in complex with the Gn head reveals their binding interfaces, directly validating the epitope residues identified by DMS. Our study delineates the antigenic landscape of SFTSV Gn, identifies potent therapeutic candidates, and establishes DMS coupled with structural validation as a powerful framework for antibody discovery against bunyaviruses.
External linksCell Rep / PubMed:41955097
MethodsEM (single particle)
Resolution2.69 - 2.97 Å
Structure data

67523

21ao

EMDB-67523, PDB-21ao:
Epitope and functional classification of human neutralizing antibodies against SFTSV Gn
Method: EM (single particle) / Resolution: 2.85 Å

67524

21aq

EMDB-67524, PDB-21aq:
Epitope and functional classification of human neutralizing antibodies against SFTSV Gn
Method: EM (single particle) / Resolution: 2.97 Å

67539

21au

EMDB-67539, PDB-21au:
Epitope and functional classification of human neutralizing antibodies against SFTSV Gn
Method: EM (single particle) / Resolution: 2.69 Å

67541

21av

EMDB-67541, PDB-21av:
Epitope and functional classification of human neutralizing antibodies against SFTSV Gn
Method: EM (single particle) / Resolution: 2.69 Å

Source
  • homo sapiens (human)
  • severe fever with thrombocytopenia syndrome virus
KeywordsVIRAL PROTEIN / SFTSV / complex

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