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Structure paper

TitleLocking Spike Domain 0 Conformation Impairs Fusion and Neutralizes Porcine Epidemic Diarrhea Virus
Journal, issue, pagesTo Be Published
Publish dateNov 13, 2025 (structure data deposition date)
AuthorsWang S / Liu JB / Wang JJ / Su MZ / Li ZM / Wang ZC / Ma Y / Li Y / Liu BH / Zou JH ...Wang S / Liu JB / Wang JJ / Su MZ / Li ZM / Wang ZC / Ma Y / Li Y / Liu BH / Zou JH / Zhu XR / Habib G / Cheng YQ / Li HY / Zhou M / Li M / Liu YT / He J / Xiao SB / Li WT / Chen XW / Zhou HB / Xiong XL
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.2 - 3.8 Å
Structure data

67062

9xnx

EMDB-67062, PDB-9xnx:
Focus refinement of PEDV HNXX spike monomer with D0 up
Method: EM (single particle) / Resolution: 2.69 Å

67063

9xny

EMDB-67063, PDB-9xny:
Focus refinement of PEDV HNXX spike monomer with D0 down in complex with N19 Fab
Method: EM (single particle) / Resolution: 2.2 Å

67066

9xo1

EMDB-67066, PDB-9xo1:
PEDV HNXX spike trimer with two D0 down in complex with two N19 Fabs
Method: EM (single particle) / Resolution: 2.42 Å

67067

9xo2

EMDB-67067, PDB-9xo2:
PEDV HNXX spike trimer with one D0 Down in complex with one N19 Fab
Method: EM (single particle) / Resolution: 2.71 Å

67068

9xo3

EMDB-67068, PDB-9xo3:
PEDV HNXX spike trimer with one D0 down
Method: EM (single particle) / Resolution: 3.8 Å

67069

9xo4

EMDB-67069, PDB-9xo4:
PEDV HNXX spike trimer with two D0 down
Method: EM (single particle) / Resolution: 3.69 Å

67070

9xo5

EMDB-67070, PDB-9xo5:
PEDV HNXX S trimer with three D0 down
Method: EM (single particle) / Resolution: 3.75 Å

82402

43yy

EMDB-82402, PDB-43yy:
Cryo-EM structure of N19 Fab : D0D-S1A
Method: EM (single particle) / Resolution: 2.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-PAM:
PALMITOLEIC ACID

Source
  • porcine epidemic diarrhea virus
  • sus scrofa (pig)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / N19 Fab / D0D-S1A / VIRAL PROTEIN-IMMUNE SYSTEM complex / VIRAL PROTEIN / PEDV-S protein / Antibody Fab fragment / Complex

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