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-Structure paper
| Title | Structural mechanism of SAM-AMP synthesis by the type III-D2 CRISPR effector complex |
|---|---|
| Journal, issue, pages | To Be Published |
| Publish date | Sep 25, 2025 (structure data deposition date) |
Authors | Mitsuda Y / Sugaya M / Ishikawa J / Nagahata N / Okazaki S / Hiraizumi M / Kato K / Gootenberg JS / Abudayyeh OO / Osawa T ...Mitsuda Y / Sugaya M / Ishikawa J / Nagahata N / Okazaki S / Hiraizumi M / Kato K / Gootenberg JS / Abudayyeh OO / Osawa T / Yamashita K / Nishimasu H |
External links | Search PubMed |
| Methods | EM (single particle) |
| Resolution | 2.6 - 2.9 Å |
| Structure data | EMDB-66346, PDB-9wxh: EMDB-66347, PDB-9wxi: EMDB-66348, PDB-9wxj: ![]() EMDB-69899: Cryo-EM structure of the type III-D2 CRISPR-Cas effector complex bound to a cognate target RNA in the pre-cleavage state ![]() EMDB-69900: Cryo-EM structure of the type III-D2 CRISPR-Cas effector complex bound to a cognate target RNA in the post-cleavage state ![]() EMDB-69901: Cryo-EM structure of the type III-D2 CRISPR-Cas effector complex bound to a non-cognate target RNA in the pre-cleavage state |
| Chemicals | ![]() ChemComp-MG: ![]() ChemComp-ANP: ![]() ChemComp-SAM: ![]() ChemComp-ZN: ![]() ChemComp-HOH: |
| Source |
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Keywords | IMMUNE SYSTEM / CRISPR / Anti-phage defense / Second messenger / SAM-AMP |
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gammaproteobacteria bacterium (bacteria)
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